Brain volumes in late life: gender, hormone treatment, and estrogen receptor variants.
Identifieur interne : 003B67 ( Main/Exploration ); précédent : 003B66; suivant : 003B68Brain volumes in late life: gender, hormone treatment, and estrogen receptor variants.
Auteurs : Joanne Ryan [Australie] ; Sylvaine Artero ; Isabelle Carrière ; Jacqueline Scali ; Jerome J. Maller ; Chantal Meslin ; Karen Ritchie ; Pierre-Yves Scarabin ; Marie-Laure AncelinSource :
- Neurobiology of aging [ 1558-1497 ] ; 2014.
Descripteurs français
- KwdFr :
- Allèles, Atrophie (génétique), Caractères sexuels, Encéphale (anatomopathologie), Femelle, Humains, Imagerie par résonance magnétique, Mâle, Oestradiol (administration et posologie), Oestrogénothérapie substitutive, Polymorphisme génétique, Progestérone (administration et posologie), Récepteur alpha des oestrogènes (génétique), Récepteur bêta des oestrogènes (génétique), Sujet âgé, Vieillissement (anatomopathologie).
- MESH :
- administration et posologie : Oestradiol, Progestérone.
- anatomopathologie : Encéphale, Vieillissement.
- génétique : Atrophie, Récepteur alpha des oestrogènes, Récepteur bêta des oestrogènes.
- Allèles, Caractères sexuels, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Oestrogénothérapie substitutive, Polymorphisme génétique, Sujet âgé.
English descriptors
- KwdEn :
- Aged, Aging (pathology), Alleles, Atrophy (genetics), Brain (pathology), Estradiol (administration & dosage), Estrogen Receptor alpha (genetics), Estrogen Receptor beta (genetics), Estrogen Replacement Therapy, Female, Humans, Magnetic Resonance Imaging, Male, Polymorphism, Genetic, Progesterone (administration & dosage), Sex Characteristics.
- MESH :
- chemical , administration & dosage : Estradiol, Progesterone.
- genetics : Atrophy, Estrogen Receptor alpha, Estrogen Receptor beta.
- pathology : Aging, Brain.
- Aged, Alleles, Estrogen Replacement Therapy, Female, Humans, Magnetic Resonance Imaging, Male, Polymorphism, Genetic, Sex Characteristics.
Abstract
Structural imaging studies suggest gender differences in brain volumes; however, whether hormone treatment (HT) can protect against age-related structural changes remains unknown, and no prior neuroimaging study has investigated potential interactions between HT and estrogen receptor (ESR) polymorphisms. Magnetic resonance imaging was used to measure gray and white matter, hippocampal volume, corpus callosum, cerebrospinal fluid (CSF), total intracranial volume (ICV) and white matter lesions (WML) in 582 non-demented older adults. In multivariable analysis, when compared to women who had never used HT, men and women currently on treatment, but not past users, had significantly smaller ratios of gray matter to ICV and increased atrophy (CSF/ICV ratio). Hippocampal and white matter volume as well as the corpus callosum area were not significantly different across groups. ESR2 variants were not significantly associated with brain measures, but women with the ESR1 rs2234693 C allele had significantly smaller WML. Furthermore this association was modified by HT use. Our results do not support a beneficial effect of HT on brain volumes in older women, but suggest the potential involvement of ESR1 in WML.
DOI: 10.1016/j.neurobiolaging.2013.09.026
PubMed: 24269019
Affiliations:
- Australie
- Languedoc-Roussillon, Occitanie (région administrative)
- Montpellier
- Université Montpellier 1
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Le document en format XML
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Maller</name></author><author><name sortKey="Meslin, Chantal" sort="Meslin, Chantal" uniqKey="Meslin C" first="Chantal" last="Meslin">Chantal Meslin</name></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></author><author><name sortKey="Scarabin, Pierre Yves" sort="Scarabin, Pierre Yves" uniqKey="Scarabin P" first="Pierre-Yves" last="Scarabin">Pierre-Yves Scarabin</name></author><author><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="eISSN">1558-1497</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aging (pathology)</term><term>Alleles</term><term>Atrophy (genetics)</term><term>Brain (pathology)</term><term>Estradiol (administration & dosage)</term><term>Estrogen Receptor alpha (genetics)</term><term>Estrogen Receptor beta (genetics)</term><term>Estrogen Replacement Therapy</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Polymorphism, Genetic</term><term>Progesterone (administration & dosage)</term><term>Sex Characteristics</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term><term>Atrophie (génétique)</term><term>Caractères sexuels</term><term>Encéphale (anatomopathologie)</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Oestradiol (administration et posologie)</term><term>Oestrogénothérapie substitutive</term><term>Polymorphisme génétique</term><term>Progestérone (administration et posologie)</term><term>Récepteur alpha des oestrogènes (génétique)</term><term>Récepteur bêta des oestrogènes (génétique)</term><term>Sujet âgé</term><term>Vieillissement (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Estradiol</term><term>Progesterone</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Oestradiol</term><term>Progestérone</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Atrophy</term><term>Estrogen Receptor alpha</term><term>Estrogen Receptor beta</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Atrophie</term><term>Récepteur alpha des oestrogènes</term><term>Récepteur bêta des oestrogènes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Estrogen Replacement Therapy</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Polymorphism, Genetic</term><term>Sex Characteristics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Allèles</term><term>Caractères sexuels</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Oestrogénothérapie substitutive</term><term>Polymorphisme génétique</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Structural imaging studies suggest gender differences in brain volumes; however, whether hormone treatment (HT) can protect against age-related structural changes remains unknown, and no prior neuroimaging study has investigated potential interactions between HT and estrogen receptor (ESR) polymorphisms. Magnetic resonance imaging was used to measure gray and white matter, hippocampal volume, corpus callosum, cerebrospinal fluid (CSF), total intracranial volume (ICV) and white matter lesions (WML) in 582 non-demented older adults. In multivariable analysis, when compared to women who had never used HT, men and women currently on treatment, but not past users, had significantly smaller ratios of gray matter to ICV and increased atrophy (CSF/ICV ratio). Hippocampal and white matter volume as well as the corpus callosum area were not significantly different across groups. ESR2 variants were not significantly associated with brain measures, but women with the ESR1 rs2234693 C allele had significantly smaller WML. Furthermore this association was modified by HT use. Our results do not support a beneficial effect of HT on brain volumes in older women, but suggest the potential involvement of ESR1 in WML.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li></settlement><orgName><li>Université Montpellier 1</li></orgName></list><tree><noCountry><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><name sortKey="Carriere, Isabelle" sort="Carriere, Isabelle" uniqKey="Carriere I" first="Isabelle" last="Carrière">Isabelle Carrière</name><name sortKey="Maller, Jerome J" sort="Maller, Jerome J" uniqKey="Maller J" first="Jerome J" last="Maller">Jerome J. Maller</name><name sortKey="Meslin, Chantal" sort="Meslin, Chantal" uniqKey="Meslin C" first="Chantal" last="Meslin">Chantal Meslin</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Scali, Jacqueline" sort="Scali, Jacqueline" uniqKey="Scali J" first="Jacqueline" last="Scali">Jacqueline Scali</name><name sortKey="Scarabin, Pierre Yves" sort="Scarabin, Pierre Yves" uniqKey="Scarabin P" first="Pierre-Yves" last="Scarabin">Pierre-Yves Scarabin</name></noCountry><country name="Australie"><region name="Occitanie (région administrative)"><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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